Overcoming multidrug resistance by co-delivery of Mdr-1 and survivin-targeting RNA with reduction-responsible cationic poly(β-amino esters).

@article{Yin2012OvercomingMR,
  title={Overcoming multidrug resistance by co-delivery of Mdr-1 and survivin-targeting RNA with reduction-responsible cationic poly(β-amino esters).},
  author={Qi Yin and Jianan Shen and Lingli Chen and Zhiwen Zhang and Wangwen Gu and Yaping Li},
  journal={Biomaterials},
  year={2012},
  volume={33 27},
  pages={6495-506}
}
Multidrug resistance (MDR) remains one of the main challenges in the successful chemotherapy of human cancer. RNA interference (RNAi) strategy aiming at only one cause of MDR was widely applied, nevertheless hardly obtained satisfactory tumor-suppressing effect. In this work, a new attempt to package two kinds of RNA with different functions into one vector and reverse MDR against two different mechanisms via RNAi was carried out. A new bioreducible poly (β-amino esters) (PAEs), poly[bis(2… CONTINUE READING

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