Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors.

Abstract

Traditionally, the goal of nanoparticle-based chemotherapy has been to decrease normal tissue toxicity by improving drug specificity to tumors. The enhanced permeability and retention effect can permit passive accumulation into tumor interstitium. However, suboptimal delivery is achieved with most nanoparticles because of heterogeneities of vascular… (More)
DOI: 10.1158/0008-5472.CAN-12-1683

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Cite this paper

@article{Manzoor2012OvercomingLI, title={Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors.}, author={Ashley A Manzoor and Lars Lindner and Chelsea D. Landon and Ji-Young Park and Andrew Joseph Simnick and Matthew R. Dreher and Shiva K. Das and Gabi Hanna and Won Park and Ashutosh Chilkoti and Gerben A. Koning and Timo L. M. ten Hagen and David M. Needham and Mark W. Dewhirst}, journal={Cancer research}, year={2012}, volume={72 21}, pages={5566-75} }