Overcoming inhibition in the spindle checkpoint.

  title={Overcoming inhibition in the spindle checkpoint.},
  author={Vincent Vanoosthuyse and Kevin G Hardwick},
  journal={Genes & development},
  volume={23 24},
Spindle checkpoint silencing is a critical step during mitosis that initiates chromosome segregation, yet surprisingly little is known about its mechanism. Protein phosphatase I (PP1) was shown recently to be a key player in this process, and in this issue of Genes & Deverlopment, Akiyoshi and colleagues (pp. 2887-2899) identify budding yeast Fin1p as a kinetochore-localized regulator of PP1 activity toward checkpoint targets. Here we review recent mechanistic insights and propose a working… CONTINUE READING