Overcoming heterogeneity in pediatric asthma: tobacco smoke and asthma characteristics within phenotypic clusters in an African American cohort.

@article{Benton2010OvercomingHI,
  title={Overcoming heterogeneity in pediatric asthma: tobacco smoke and asthma characteristics within phenotypic clusters in an African American cohort.},
  author={Angela S. Benton and Zuyi Wang and Jennifer Block Lerner and Matthew Foerster and Stephen J. Teach and Robert J Freishtat},
  journal={The Journal of asthma : official journal of the Association for the Care of Asthma},
  year={2010},
  volume={47 7},
  pages={
          728-34
        }
}
OBJECTIVE Asthma in children and adolescents is a heterogeneous syndrome comprised of multiple subgroups with variable disease expression and response to environmental exposures. The goal of this study was to define homogeneous phenotypic clusters within a cohort of children and adolescents with asthma and to determine overall and within-cluster associations between environmental tobacco smoke (ETS) exposure and asthma characteristics. METHODS A combined hierarchical/k-means cluster analysis… CONTINUE READING
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