Overcoming drug resistance by regulating nuclear receptors.

  title={Overcoming drug resistance by regulating nuclear receptors.},
  author={Taosheng Chen},
  journal={Advanced drug delivery reviews},
  volume={62 13},
Drug resistance involves multiple mechanisms. Multidrug resistance (MDR) is the leading cause of treatment failure in cancer therapy. Elevated levels of MDR proteins [members of the ATP-binding cassette (ABC) transporter family] increase cellular efflux and decrease the effectiveness of chemotherapeutic agents. As a salvage approach to overcome drug resistance, inhibitors of MDR proteins have been developed, but have had limited success mainly due to undesired toxicities. Nuclear receptors (NRs… CONTINUE READING


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