Overcoming drug resistance by enhancing apoptosis of tumor cells.

@article{GimnezBonaf2009OvercomingDR,
  title={Overcoming drug resistance by enhancing apoptosis of tumor cells.},
  author={Pepita Gim{\'e}nez-Bonaf{\'e} and Avelina Tortosa and Ricardo P{\'e}rez-Tom{\'a}s},
  journal={Current cancer drug targets},
  year={2009},
  volume={9 3},
  pages={
          320-40
        }
}
Drug resistance remains a major clinical challenge for cancer treatment. One mechanism by which tumor cells develop resistance to cytotoxic agents and radiation is related to resistance to apoptosis. Apoptosis is a well-organised process of cell death pre-programmed inside the cell. Apoptosis can be initiated either by activation of death receptors on the cell surface membranes (extrinsic pathway) or through a series of cellular events primarily processed at mitochondria (intrinsic pathway… CONTINUE READING

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