Overcoming conduction failure in demyelinated nerve fibres by prolonging action potentials

@article{Bostock1978OvercomingCF,
  title={Overcoming conduction failure in demyelinated nerve fibres by prolonging action potentials},
  author={Hugh Bostock and R. M. Sherratt and Thomas A. Sears},
  journal={Nature},
  year={1978},
  volume={274},
  pages={385-387}
}
LOSS of myelin from central or peripheral myelinated nerve fibres results in conduction delays, increased refractoriness and, above all, conduction block1,2. Conduction failure could result either because a demyelinated axon is electrically inexcitable, or because the limited current available from a normal node is insufficient to excite it. Because continuous conduction along demyelinated internodes has been observed3, it seems likely that demyelinated axons in general are able to conduct… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Myelination and Demyelination

Springer US • 1989
View 9 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…