Overcoming challenges and dogmas to understand the functions of pseudogenes

@article{Cheetham2019OvercomingCA,
  title={Overcoming challenges and dogmas to understand the functions of pseudogenes},
  author={Seth W. Cheetham and Geoffrey J. Faulkner and M. Dinger},
  journal={Nature Reviews Genetics},
  year={2019},
  volume={21},
  pages={191-201}
}
Pseudogenes are defined as regions of the genome that contain defective copies of genes. They exist across almost all forms of life, and in mammalian genomes are annotated in similar numbers to recognized protein-coding genes. Although often presumed to lack function, growing numbers of pseudogenes are being found to play important biological roles. In consideration of their evolutionary origins and inherent limitations in genome annotation practices, we posit that pseudogenes have been… 
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