Overcoming an Extremely Drug Resistant (XDR) Pathogen: Avibactam Restores Susceptibility to Ceftazidime for Burkholderia cepacia Complex Isolates from Cystic Fibrosis Patients.

@article{PappWallace2017OvercomingAE,
  title={Overcoming an Extremely Drug Resistant (XDR) Pathogen: Avibactam Restores Susceptibility to Ceftazidime for Burkholderia cepacia Complex Isolates from Cystic Fibrosis Patients.},
  author={Krisztina M Papp-Wallace and Scott A Becka and Elise T Zeiser and Nozomi Ohuchi and Maria F. Mojica and Julian A Gatta and Monica Falleni and Delfina Tosi and Elisa Borghi and Marisa L. Winkler and Brigid M. Wilson and John J LiPuma and Michiyoshi Nukaga and Robert A. Bonomo},
  journal={ACS infectious diseases},
  year={2017},
  volume={3 7},
  pages={
          502-511
        }
}
Burkholderia multivorans is a significant health threat to persons with cystic fibrosis (CF). Infections are difficult to treat as this pathogen is inherently resistant to multiple antibiotics. Susceptibility testing of isolates obtained from CF respiratory cultures revealed that single agents selected from different antibiotic classes were unable to inhibit growth. However, all isolates were found to be susceptible to ceftazidime when combined with the novel non-β-lactam β-lactamase inhibitor… CONTINUE READING
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