Overcoming Resistance to 5-Azacytidine in Acute Myelogenous Leukemia

  title={Overcoming Resistance to 5-Azacytidine in Acute Myelogenous Leukemia},
  author={Piyanuch Sripayap and T. Nagai and Mitsuyo Uesawa and Hiroyuki Kobayashi and T. Tsukahara and K. Ohmine and K. Muroi and Gary Baley and K. Ozawa},
Abstract 1370 Background: The DNA methylation inhibitor 5-azacytidine (AZA), which is approved for treatment of myelodysplastic syndrome, is also a potential agent for treatment of leukemia; however, drug resistance is an ongoing problem, and mechanisms underlying developing resistance to AZA are poorly understood. Therefore, clarifying the resistance mechanisms is central to establish effective countermeasures. Methods: To probe the mechanisms of resistance to AZA and to develop an effective… Expand