Overcoming Downstream Purification Challenges for Viral Vector Manufacturing: Enabling Advancement of Gene Therapies in the Clinic

  title={Overcoming Downstream Purification Challenges for Viral Vector Manufacturing: Enabling Advancement of Gene Therapies in the Clinic},
  author={Orjana Terova and Steven M Soltys and Pim W Hermans and Jessica D. de Rooij and Frank J. M. Detmers},
The adeno-associated vector (AAV) has shown great potential for the delivery of therapeutic genes in the gene therapy field and has become a vector of choice for many therapies. Although excellent clinical outcomes have been reported, the current potential of viral vectors in the clinic is limited due to manufacturing challenges including the absence of an efficient and scalable platform purification process. Affinity chromatography has proven to be a viable solution for the purification of… 

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