Overcoming Antigen Escape with CAR T-cell Therapy.

  title={Overcoming Antigen Escape with CAR T-cell Therapy.},
  author={Hollie J. Jackson and Renier J. Brentjens},
  journal={Cancer discovery},
  volume={5 12},
Sotillo and colleagues describe the molecular events associated with apparent loss of target antigen expression following CAR T-cell therapy. We propose that broader immune activation is required to prevent outgrowth of tumor antigen escape variants following targeted therapies. 
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