Overactivation of intestinal sterol response element-binding protein 2 promotes diet-induced nonalcoholic steatohepatitis.

@article{Malhotra2017OveractivationOI,
  title={Overactivation of intestinal sterol response element-binding protein 2 promotes diet-induced nonalcoholic steatohepatitis.},
  author={Pooja Malhotra and Costica Aloman and Aparna Ankireddy and Hani Khadra and Kohtaro Ooka and Ravinder Kaur Gill and Seema Saksena and Pradeep K. Dudeja and Waddah A. Alrefai},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2017},
  volume={313 5},
  pages={
          G376-G385
        }
}
Nonalcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation in the liver that may progress to hepatic fibrosis and nonalcoholic steatohepatitis (NASH). Mechanisms underlying NAFLD and NASH are not yet fully understood. Dietary cholesterol was recently shown to be a risk factor for the development of NASH, suggesting a role for intestinal handling of cholesterol. One important regulator of cholesterol homeostasis is the sterol response element-binding protein-2 (SREBP-2… CONTINUE READING
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