Over-the-counter vitamin K1-containing multivitamin supplements disrupt warfarin anticoagulation in vitamin K1-depleted patients. A prospective, controlled trial.

@article{Kurnik2004OverthecounterVK,
  title={Over-the-counter vitamin K1-containing multivitamin supplements disrupt warfarin anticoagulation in vitamin K1-depleted patients. A prospective, controlled trial.},
  author={D. Kurnik and R. Loebstein and H. Rabinovitz and N. Austerweil and H. Halkin and S. Almog},
  journal={Thrombosis and haemostasis},
  year={2004},
  volume={92 5},
  pages={
          1018-24
        }
}
  • D. Kurnik, R. Loebstein, +3 authors S. Almog
  • Published 2004
  • Medicine
  • Thrombosis and haemostasis
  • Most multivitamin supplements contain far less vitamin K(1) than thought to affect warfarin anticoagulation. Having described 3 patients with multivitamin-warfarin interactions, we hypothesized that vitamin K(1)-depleted patients are sensitive to even small increments. Therefore, we compared the effect of a vitamin K(1)-containing multivitamin on warfarin anticoagulation between patients with low versus normal vitamin K(1) status. We screened 102 warfarin-treated patients and recruited nine… CONTINUE READING
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