Over-the-counter vitamin K1-containing multivitamin supplements disrupt warfarin anticoagulation in vitamin K1-depleted patients. A prospective, controlled trial.

@article{Kurnik2004OverthecounterVK,
  title={Over-the-counter vitamin K1-containing multivitamin supplements disrupt warfarin anticoagulation in vitamin K1-depleted patients. A prospective, controlled trial.},
  author={Daniel Kurnik and Ronen Loebstein and Hadas Rabinovitz and Naomi Austerweil and Hillel Halkin and Shlomo Almog},
  journal={Thrombosis and haemostasis},
  year={2004},
  volume={92 5},
  pages={1018-24}
}
Most multivitamin supplements contain far less vitamin K(1) than thought to affect warfarin anticoagulation. Having described 3 patients with multivitamin-warfarin interactions, we hypothesized that vitamin K(1)-depleted patients are sensitive to even small increments. Therefore, we compared the effect of a vitamin K(1)-containing multivitamin on warfarin anticoagulation between patients with low versus normal vitamin K(1) status. We screened 102 warfarin-treated patients and recruited nine… CONTINUE READING

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