Over-the-Counter Supplement Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia

@article{Butler2018OvertheCounterSI,
  title={Over-the-Counter Supplement Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia},
  author={Mary E Butler and Victoria A. Nelson and Heather Davila and Edward R. Ratner and Howard A Fink and Laura Sue Hemmy and John Riley McCarten and Terry R. Barclay and Michelle Brasure and Robert Kane},
  journal={Annals of Internal Medicine},
  year={2018},
  volume={168},
  pages={52-62}
}
Fear of losing cognitive ability to Alzheimer disease and related dementias drives a growing industry of over-the-counter (OTC) supplements intended to boost brain health and prevent or slow cognitive decline. The Alzheimer's Research and Prevention Foundation recommends that people be sure to take [their] vitamins and memory-specific nutrients and suggests optimal dosages for an array of vitamins and nutrients (1). An estimated 63% of older adults use OTC supplements (2). In 2015, Americans… Expand
Nutritional prevention of cognitive decline and dementia
TLDR
The evidence for the effects of some dietary components, supplements, and dietary patterns as neuroprotective, with potential to delay cognitive decline and the onset of dementia are evaluated. Expand
Trends in the Use of Medications and Supplements to Treat or Prevent Dementia
TLDR
The use of both prescription drugs and supplements increased over time, except for decreases in ginkgo and vitamin E, and prescription drug use appeared in line with prescribing guidelines. Expand
Nutrition to Prevent or Treat Cognitive Impairment in Older Adults: A GRADE Recommendation
TLDR
In conclusion, nutrition is an important modifiable factor to prevent or protect against cognitive decline, Nevertheless, more studies are required to determine specific guidelines such as duration and amounts of nutrients to help older adult to maintain a healthy cognitive life. Expand
Dietary Supplements for Brain Health-Reply.
TLDR
It is concluded that, in the appropriate subgroup, it is possible to prevent or slow cognitive decline with a dietary supplement. Expand
Efficacy and Safety of Sesame Oil Cake Extract on Memory Function Improvement: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Pilot Study
  • Su-Jin Jung, Eun-Soo Jung, +6 authors Young-Chul Chung
  • Medicine
  • Nutrients
  • 2021
The goal of treatment for mild cognitive impairment (MCI) is to reduce the existing clinical symptoms, delay the progression of cognitive impairment and prevent the progression to Alzheimer’s diseaseExpand
Mild Cognitive Impairment in Clinical Practice: A Review Article
TLDR
Lifestyle modification, such as aerobic exercise, is an approved modality to preserve cognitive ability and decrease the rate of progression to dementia, as well as being recommended for frailty prevention. Expand
Homocysteine: A modifiable culprit of cognitive impairment for us to conquer?
TLDR
More studies are required to better explain the related pathophysiological mechanisms, improve experimental methods, and investigate the preventive or/and therapeutic effects of homocysteine-lowering strategies on cognitive impairment. Expand
Prevention of Cognitive Decline in Alzheimer’s Disease by Novel Antioxidative Supplements
TLDR
The interplay between oxidative stress and the Aβ cascade is summarized, novel antioxidative supplements expected to prevent cognitive decline in AD are introduced, and they can be beneficial for AD patients. Expand
Update on Treatments for Cognitive Decline in Alzheimer’s Disease
TLDR
Alzheimer's disease is a progressive neurodegenerative disorder and a leading cause of dementia in the elderly; however new therapies are in the pipeline and discovery of biomarkers make early diagnosis and future treatment of AD hopeful. Expand
A meta-analysis of peripheral tocopherol levels in age-related cognitive decline and Alzheimer's disease.
TLDR
It is suggested that lower α-tocopherol levels have a strong association with AD and MCI supporting evidence for the role of diet and vitamin E in AD risk and age-related cognitive decline. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 62 REFERENCES
Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment.
TLDR
The primary efficacy outcomes were the incidence of dementia and scores on measures of overall cognitive function and the risk of bias of included studies using the Cochrane 'Risk of bias' assessment tool. Expand
Preventing Alzheimer's disease and cognitive decline.
TLDR
The current research on the list of putative risk or protective factors is largely inadequate to confidently assess their association with AD or cognitive decline, and further research that addresses the limitations of existing studies is needed to be able to make recommendations on interventions. Expand
Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment
TLDR
The results show that B-vitamin supplementation can slow the atrophy of specific brain regions that are a key component of the AD process and that are associated with cognitive decline, and further trials focusing on elderly subjets with high homocysteine levels are warranted. Expand
Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer’s Disease by Vitamin E and Selenium Trial (PREADViSE)
TLDR
This is the first study to investigate the long-term association of antioxidant supplement use and dementia incidence among asymptomatic men and found neither supplement prevented dementia. Expand
Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment
TLDR
Data from this trial is used to see whether baseline omega-3 fatty acid status interacts with the effects of B vitamin treatment, and higher concentrations of docosahexaenoic acid alone significantly enhanced the cognitive effects ofB vitamins, while eicosapentaenoic acids appeared less effective. Expand
Vitamin E and donepezil for the treatment of mild cognitive impairment.
TLDR
Vitamin E had no benefit in patients with mild cognitive impairment and donepezil therapy was associated with a lower rate of progression to Alzheimer's disease during the first 12 months of treatment, a finding supported by the secondary outcome measures. Expand
B-vitamins and fatty acids in the prevention and treatment of Alzheimer's disease and dementia: a systematic review.
TLDR
The available evidence is insufficient to draw definitive conclusions on the association of B vitamins and fatty acids with cognitive decline or dementia, and further long-term trials are required. Expand
Ginkgo biloba for prevention of dementia: a randomized controlled trial.
TLDR
In this study, G. biloba at 120 mg twice a day was not effective in reducing either the overall incidence rate of dementia or AD incidence in elderly individuals with normal cognition or those with mild cognitive impairment. Expand
Long-Term Multivitamin Supplementation and Cognitive Function in Men
TLDR
In male physicians aged 65 years or older, long-term use of a daily multivitamin did not provide cognitive benefits and doses of vitamins may be too low or the population may beToo well-nourished to benefit from a multiv vitamin. Expand
Omega 3 fatty acid for the prevention of cognitive decline and dementia.
TLDR
The available trials showed no benefit of omega-3 PUFA supplementation on cognitive function in cognitively healthy older people and the main reported side-effect was mild gastrointestinal problems. Expand
...
1
2
3
4
5
...