Over-expression of wild-type Securin leads to aneuploidy in human cells.

@article{Christopoulou2003OverexpressionOW,
  title={Over-expression of wild-type Securin leads to aneuploidy in human cells.},
  author={Lina Christopoulou and Jonathan D. Moore and Chris Tyler-Smith},
  journal={Cancer letters},
  year={2003},
  volume={202 2},
  pages={213-8}
}
Changes in gene expression and aneuploidy are both common features of cancers and under- or over-expression of single genes can cause aneuploidy. Securin, which is involved in chromatid separation, has transforming activity in vitro and is over-expressed in many tumours. We have used a GFP-based assay for chromosome loss in human cells to investigate the… CONTINUE READING