Over-expression of the chondroitin sulphate proteoglycan versican is associated with defective neural crest migration in the Pax3 mutant mouse (splotch)

@article{Henderson1997OverexpressionOT,
  title={Over-expression of the chondroitin sulphate proteoglycan versican is associated with defective neural crest migration in the Pax3 mutant mouse (splotch)},
  author={Deborah J Henderson and Patricia Ybot-Gonz{\'a}lez and Andrew J Copp},
  journal={Mechanisms of Development},
  year={1997},
  volume={69},
  pages={39-51}
}
Splotch mice, which harbour mutations in the Pax3 gene, exhibit neural crest-related abnormalities including pigmentation defects, reduced or absent dorsal root ganglia and failure of cardiac outflow tract septation in homozygotes. Although splotch neural crest cells fail to colonise target tissues, they initiate migration in vivo and appear to migrate as well as wild type neural crest cells in vitro, suggesting that the neural crest abnormality in splotch may reside not in the neural crest… CONTINUE READING

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