Over-expression of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis.

@article{Sasaki2008OverexpressionOP,
  title={Over-expression of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis.},
  author={Mitsuho Sasaki and Jon Yamaguchi and Keita Itatsu and Hiroko Ikeda and Yasuni Nakanuma},
  journal={The Journal of pathology},
  year={2008},
  volume={215 2},
  pages={
          175-83
        }
}
  • Mitsuho Sasaki, Jon Yamaguchi, +2 authors Yasuni Nakanuma
  • Published in The Journal of pathology 2008
  • Biology, Medicine
  • Polycomb group protein EZH2 and Bmi1 are reportedly involved in the progression of malignant tumours. We examined the participation of EZH2 in multi-step cholangiocarcinogenesis in hepatolithiasis with respect to tumour suppressor gene p16 INK4a. We examined 20 hepatolithiatic livers with intrahepatic cholangiocarcinoma (ICC) and 10 histologically normal livers. Neoplastic biliary lesions were classified into biliary intraepithelial neoplasm (BilIN-1, 2 and 3) and invasive carcinoma. We… CONTINUE READING

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