Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemia.

@article{Li2009OverexpressionOC,
  title={Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemia.},
  author={X Li and Ying Li and Limei Shan and Enqing Shen and Ruizhen Chen and Tianqing Peng},
  journal={Cardiovascular research},
  year={2009},
  volume={83 1},
  pages={72-9}
}
AIMS Lipopolysaccharide (LPS) induces cardiomyocyte caspase-3 activation and proinflammatory factors, in particular tumour necrosis factor-alpha (TNF-alpha) production, both of which contribute to myocardial dysfunction during sepsis. The present study was to investigate the roles of calpain/calpastatin system in cardiomyocyte caspase-3 activation, TNF-alpha expression, and myocardial dysfunction during LPS stimulation. METHODS AND RESULTS In cultured adult rat cardiomyocytes, LPS (1 microg… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

Calpains and Coronary Vascular Disease.

Circulation journal : official journal of the Japanese Circulation Society • 2016
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 48 references

The calpain system.

Physiological reviews • 2003
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…