Over-expression of ST3Gal-I promotes mammary tumorigenesis

  title={Over-expression of ST3Gal-I promotes mammary tumorigenesis},
  author={Gianfranco Picco and Sylvain Julien and Inka Brockhausen and Richard E Beatson and Aristotelis Antonopoulos and Stuart M. Haslam and Ulla Mandel and Anne Dell and Sarah Pinder and Joyce Taylor-Papadimitriou and Joy Burchell},
Changes in glycosylation are common in malignancy, and as almost all surface proteins are glycosylated, this can dramatically affect the behavior of tumor cells. In breast carcinomas, the O-linked glycans are frequently truncated, often as a result of premature sialylation. The sialyltransferase ST3Gal-I adds sialic acid to the galactose residue of core 1 (Galbeta1,3GalNAc) O-glycans and this enzyme is over-expressed in breast cancer resulting in the expression of sialylated core 1 glycans. In… CONTINUE READING
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Biosynthesis of complex mucin-type O-glycans

  • I. Brockhausen
  • In: Wang G, editor. Comprehensive Natural…
  • 2009
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