Over-expression of Rap2a inhibits glioma migration and invasion by down-regulating p-AKT.

@article{Wang2014OverexpressionOR,
  title={Over-expression of Rap2a inhibits glioma migration and invasion by down-regulating p-AKT.},
  author={Lei Wang and Wenjian Zhan and Shao Hua Xie and Jinxia Hu and Qiong Shi and Xiuping Zhou and Yuxuan Wu and Shiquan Wang and Zhou Fei and Rutong Yu},
  journal={Cell biology international},
  year={2014},
  volume={38 3},
  pages={326-34}
}
Ras-oncogenic pathway contributes to the pathogenesis of various tumours in humans, in which mutations of three canonical genes including H-Ras, N-Ras and K-Ras are the most common events. Dysregulation of Ras signalling can be tumourigenic, especially gliomas of the central nervous system. Rap proteins are members of the small GTPase superfamily that… CONTINUE READING