Over-expression of N-type calcium channels in cortical neurons from a mouse model of Amyotrophic Lateral Sclerosis

@article{Pieri2013OverexpressionON,
  title={Over-expression of N-type calcium channels in cortical neurons from a mouse model of Amyotrophic Lateral Sclerosis},
  author={Massimo Pieri and Silvia Caioli and Nadia Canu and Nicola Biagio Mercuri and Cristina Zona},
  journal={Experimental Neurology},
  year={2013},
  volume={247},
  pages={349-358}
}
Voltage-gated Ca(2+) channels (VGCCs) mediate calcium entry into neuronal cells in response to membrane depolarisation and play an essential role in a variety of physiological processes. In Amyotrophic Lateral Sclerosis (ALS), a fatal neurodegenerative disease caused by motor neuron degeneration in the brain and spinal cord, intracellular calcium dysregulation has been shown, while no studies have been carried out on VGCCs. Here we show that the subtype N-type Ca(2+) channels are over expressed… CONTINUE READING
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