Over-expression of Kv1.5 in rat cardiomyocytes extremely shortens the duration of the action potential and causes rapid excitation.

@article{Tanabe2006OverexpressionOK,
  title={Over-expression of Kv1.5 in rat cardiomyocytes extremely shortens the duration of the action potential and causes rapid excitation.},
  author={Yasutaka Tanabe and Katsuharu Hatada and Naoki Naito and Yoshiyasu Aizawa and Masaomi Chinushi and Hiroyuki Nawa and Yoshifusa Aizawa},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={345 3},
  pages={
          1116-21
        }
}
BACKGROUND Genetically abnormal action potential duration (APD) can be a cause of arrhythmias that include long and short QT interval syndrome. PURPOSE The aim of this study was to evaluate the arrhythmogenic effect of short QT syndrome induced by the over-expression of Kv1.5 in rat. METHODS From Sprague-Dawley rats on fetal days 18-19, cardiomyocytes were excised and cultured with and without transfection with the Kv-1.5 gene using an adenovirus vector. The expression of Kv1.5 was proven… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-7 OF 7 CITATIONS

Similar Papers

Loading similar papers…