Over-expression of FoxM1 is associated with adverse prognosis and FLT3-ITD in acute myeloid leukemia.

@article{Liu2014OverexpressionOF,
  title={Over-expression of FoxM1 is associated with adverse prognosis and FLT3-ITD in acute myeloid leukemia.},
  author={Long-long Liu and Dong-hua Zhang and Xia Mao and Xin-Hua Zhang and Bing Zhang},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={446 1},
  pages={280-5}
}
Forkhead box M1 (FoxM1) drives cell cycle progression and the prevention of growth arrest and is over-expressed in many human malignancies. However, the characteristics of FoxM1 in acute myeloid leukemia (AML) are not clearly understood. We investigated the expression level of FoxM1 and analyzed the correlation of FoxM1 expression with AML patient characteristics and prognoses. Changes in FoxM1 expression were detected after MV4-11 cells, which have an internal tandem duplication (ITD) of the… CONTINUE READING

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