Over-expression of CYP2C11, the major male-specific form of hepatic cytochrome P450, in the presence of nominal pulses of circulating growth hormone in adult male rats neonatally exposed to low levels of monosodium glutamate.

@article{Pampori1994OverexpressionOC,
  title={Over-expression of CYP2C11, the major male-specific form of hepatic cytochrome P450, in the presence of nominal pulses of circulating growth hormone in adult male rats neonatally exposed to low levels of monosodium glutamate.},
  author={Nisar A Pampori and Bernard H. Shapiro},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1994},
  volume={271 2},
  pages={1067-73}
}
Male rat pups were injected with monosodium glutamate (MSG), 4 mg/g b.wt., on either days 1 and 3 or days 1, 3, 5, 7 and 9 of life. Plasma samples obtained during 8.5 continuous hr of serial blood collections from adults, neonatally treated with five doses of MSG, contained no detectable concentrations of growth hormone. In addition, the livers of these animals contained no measurable expression levels of the major male-specific form of cytochrome P450 (CYP2C11) mRNA or its protein. In contrast… CONTINUE READING

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