Over-expressed and truncated midkines promote proliferation of BGC823 cells in vitro and tumor growth in vivo.

Abstract

AIM To determine whether midkine (MK) and its truncated form (tMK) contribute to gastric tumorigenesis using in vitro and in vivo models. METHODS Human MK and tMK plasmids were constructed and expressed in BGC823 (a gastric adenocarcinoma cell line) to investigate the effect of over-expressed MK or tMK on cell growth and turmorigenesis in nude mice… (More)

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