Over-expressed Fas improves the apoptosis of malignant T-cells in vitro and vivo

@article{Li2011OverexpressedFI,
  title={Over-expressed Fas improves the apoptosis of malignant T-cells in vitro and vivo},
  author={Linghao Li and Ri Hong Zhang and Zixing Chen and Shengli Xue and Xiuli Wang and Changgeng Ruan},
  journal={Molecular Biology Reports},
  year={2011},
  volume={38},
  pages={5371-5377}
}
Fas play a critical role in T-cell apoptosis by functioning as a major cell-surface death receptor. To explore a potential method that can improve the sensitivity to Fas-mediated apoptosis in malignant precursor T-cells. Fas gene was stable transfected into Jurkat cells to establish a new cell line named Jurkat-Fas with over-expressed Fas. RT-PCR, real-time RT-PCR, flow cytometry, and confocal microscopy assay were performed to detect the Fas level of mRNA and protein in the two cell lines. The… CONTINUE READING

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