Over-Expression of PDGFR-β Promotes PDGF-Induced Proliferation, Migration, and Angiogenesis of EPCs through PI3K/Akt Signaling Pathway

@inproceedings{Wang2012OverExpressionOP,
  title={Over-Expression of PDGFR-β Promotes PDGF-Induced Proliferation, Migration, and Angiogenesis of EPCs through PI3K/Akt Signaling Pathway},
  author={Hang Wang and Yangguang Yin and Wei Li and Xiaohui Zhao and Yonghao Yu and Jinkun Zhu and Zhexue Qin and Qiang Sheng Wang and Kui Wang and Wei Lu and Jie Liu and Lan Huang},
  booktitle={PloS one},
  year={2012}
}
The proliferation, migration, and angiogenesis of endothelial progenitor cells (EPCs) play critical roles in postnatal neovascularization and re-endothelialization following vascular injury. Here we evaluated whether the over-expression of platelet-derived growth factor receptor-β (PDGFR-β) can enhance the PDGF-BB-stimulated biological functions of EPCs through the PDGFR-β/phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. We first confirmed the expression of endogenous PDGFR-β and its… CONTINUE READING

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