Over‐the‐Counter Progesterone Cream Produces Significant Drug Exposure Compared to a Food and Drug Administration‐Approved Oral Progesterone Product

@article{Hermann2005OvertheCounterPC,
  title={Over‐the‐Counter Progesterone Cream Produces Significant Drug Exposure Compared to a Food and Drug Administration‐Approved Oral Progesterone Product},
  author={Anne C Hermann and Anne N. Nafziger and Jennifer M Victory and Robert Kulawy and Mario L. Rocci and Joseph S. Bertino},
  journal={The Journal of Clinical Pharmacology},
  year={2005},
  volume={45}
}
Progesterone products are available in prescription form as well as over‐the‐counter (OTC) topical preparations sold for “cosmetic” uses. In a randomized study design, the authors compared the drug exposure from an OTC progesterone cream to a Food and Drug Administration‐approved oral preparation at the labeled daily doses recommended for each product. Twelve healthy postmenopausal women received 200‐mg oral progesterone capsules once daily for 12 days or progesterone cream 40 mg twice daily… 

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