Over‐expression of glutamine synthetase in focal nodular hyperplasia: a novel easy diagnostic tool in surgical pathology

@article{BioulacSage2009OverexpressionOG,
  title={Over‐expression of glutamine synthetase in focal nodular hyperplasia: a novel easy diagnostic tool in surgical pathology},
  author={Paulette Bioulac-Sage and Herv{\'e} Laumonier and Anne Rullier and Gaelle Cubel and Christophe Laurent and Jessica Zucman‐Rossi and Charles Balabaud},
  journal={Liver International},
  year={2009},
  volume={29}
}
Background and Aims: Glutamine synthetase (GS) is a useful marker in tumour liver pathology, including hepatocellular adenomas and nodules in cirrhosis. We investigated the use of GS as a marker in various clinical situations, in which FNH diagnosis had been firmly established to determine its contribution to diagnosis. 
Glutamine synthetase expression in activated hepatocyte progenitor cells and loss of hepatocellular expression in congestion and cirrhosis
  • K. Fleming, I. Wanless
  • Biology, Medicine
  • Liver international : official journal of the International Association for the Study of the Liver
  • 2013
In normal human liver, glutamine synthetase (GS) is expressed in a rim of hepatocytes surrounding hepatic veins. GS expression is decreased in cirrhosis and increased in chronic hepatitis, focalExpand
Nodular Regenerative Hyperplasia: Expression Pattern of Glutamine Synthetase and a Potential Role for Hepatic Progenitor Cells
TLDR
The findings suggest that there is an activation of hepatic progenitor cells in NRH, and increased immunohistochemical GS staining that may support its morphologic diagnosis. Expand
Preserved or enhanced OATP1B3 expression in hepatocellular adenoma subtypes with nuclear accumulation of β‐catenin
  • T. Fukusato, Y. Soejima, +8 authors T. Niki
  • Biology, Medicine
  • Hepatology research : the official journal of the Japan Society of Hepatology
  • 2015
TLDR
The clinicopathological characteristics of HCA subtypes are delineated, the expression of transporter protein OATP1B3 in HCA is evaluated and the status of hepatocellular adenoma is evaluated. Expand
Immunostaining of glutamine synthetase is a sensitive and specific marker for diagnosing focal nodular hyperplasia in needle biopsy
TLDR
Immunohistochemical staining of GS increases the diagnostic sensitivity of FNH in needle biopsy, especially in those without typical morphology, and also helps in differentiating FNH from other tumourous and non-tumourous lesions. Expand
Immunohistochemistry as a surrogate for molecular diagnosis in hepatic tumours
TLDR
New molecular-based immunohistochemical markers for well-differentiated hepatocellular carcinoma, cholangiocarcinoma, liver-fatty acid binding protein, serum amyloid A, glutamine synthetase, and beta-catenin are reviewed. Expand
A triple stain of reticulin, glypican-3, and glutamine synthetase: a useful aid in the diagnosis of liver lesions.
TLDR
The triple stain of reticulin, glypican-3, and glutamine synthetae is useful in the differentiation of hepatocellular carcinoma, hepatic adenoma, and focal nodular hyperplasia on biopsy specimens and can help when aberrant staining patterns are observed. Expand
The value of immunophenotyping hepatocellular adenomas: consecutive resections at one UK centre
Aims:  To determine the utility of immunophenotyping for classification of hepatocellular adenomas resected at one Scottish centre.
Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma
TLDR
The results highlight the diagnostic errors that can be caused by variant patterns of staining with glutamine synthetase and serum amyloid-associated protein in inflammatory hepatocellular adenoma and focal nodular hyperplasia. Expand
Characterization of hepatocellular adenoma based on the phenotypic classification: The Kanazawa experience
TLDR
HCA is rare in Asian countries including Japan and there has been no study regarding the subgroups of HCA in Japan and recently four major subgroups were identified based on genotype and phenotype classification from Europe. Expand
[Interest of immunohistochemistry for the diagnosis of benign hepatocellular tumors].
TLDR
In this review, immunohistochemical characteristics described on resected specimen are suitable on biopies of these tumors, facilitating their diagnosis and therefore allowing a better management of the patients. Expand
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