Ovary and ovulation: DNA fragmentation of oocytes in aged mice

@inproceedings{Fujino1996OvaryAO,
  title={Ovary and ovulation: DNA fragmentation of oocytes in aged mice},
  author={Yuji Fujino and Keisuke Ozaki and Seiichi Yamamasu and Fumihiko Ito and Isao Matsuoka and Eiji Hayashi and Hidemitsu Nakamura and Sachio Ogita and Eisuke F. Sato and Mitsuteru Inoue},
  year={1996}
}
^To whom correspondence should be addressed To investigate whether female fertility decreases with age due to poor oocyte quality, we examined the presence of DNA fragmentation in ovulated oocytes from young, mature and aged mice. Oocytes from three age groups of female mice (7-8, 20-24 and 40-^48 weeks) were retrieved from the oviducts 15 h after human chorionic gonadotrophin (HCG) injection. Oocytes from each mouse were incubated in a CO2 incubator for 0-60 h in human tubal fluid (HTF). After… CONTINUE READING