Ovario-protective effects of genistein against cyclophosphamide toxicity in rats: Role of anti-müllerian hormone and oestradiol.

@article{Saleh2016OvarioprotectiveEO,
  title={Ovario-protective effects of genistein against cyclophosphamide toxicity in rats: Role of anti-m{\"u}llerian hormone and oestradiol.},
  author={Dalia Osama Saleh and Dina Farouk Mansour},
  journal={European journal of pharmacology},
  year={2016},
  volume={789},
  pages={163-171}
}
Cyclophosphamide (CP), the commonly used chemotherapeutic agent in cancer treatment, is proven to cause ovarian toxicity and infertility in women. In the present study, we investigated the protective effect of genistein (GEN), a phytoestrogen found in the soy protein, against CP-induced ovarian toxicity in rats. Forty female adult rats were allocated into five groups. A normal control group received the vehicle; another group was injected with a single acute intraperitoneal dose of CP (200mg/kg… CONTINUE READING

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