Ovariectomy vs. hypofunction: their effects on rat mandibular bone.

@article{Rawlinson2009OvariectomyVH,
  title={Ovariectomy vs. hypofunction: their effects on rat mandibular bone.},
  author={Simon C. F. Rawlinson and Alan Boyde and Graham R. Davis and Peter G T Howell and Francis J Hughes and Virginia J. Kingsmill},
  journal={Journal of dental research},
  year={2009},
  volume={88 7},
  pages={615-20}
}
Previous studies have suggested that the mandible may be more influenced by mechanical loading than by circulating hormone levels. We tested the hypothesis that hypofunction has a greater influence than ovariectomy on mandibular bone. Two-month-old rats were ovariectomized (OVX) or had maxillary molars removed from one side to induce unilateral mandibular hypofunction. Control animals remained untreated. After 5 months, animals were killed, and bones were assessed by micro-tomography (muCT… CONTINUE READING

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