Ovariectomy and estrogen-induced alterations in myocardial contractility in female rabbits: role of the L-type calcium channel.

@article{Patterson1998OvariectomyAE,
  title={Ovariectomy and estrogen-induced alterations in myocardial contractility in female rabbits: role of the L-type calcium channel.},
  author={Eugene Patterson and Li Ma and B. J. Szabo and Casey P. Robinson and Udho Thadani},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={284 2},
  pages={
          586-91
        }
}
The effects of ovariectomy and estrogen replacement on myocardial contractility were examined in female rabbits. Ovariectomy failed to alter left ventricular mass, papillary muscle cross-sectional area or isometric force. Estrogen replacement after ovariectomy (0.15 microg/kg/day i.m. 17beta-estradiol acetate for 7 days) increased left ventricular mass and papillary muscle mass, and reduced isometric force compared to control and ovariectomy groups. Ovariectomy did not alter increased isometric… CONTINUE READING
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