Ovariectomy and 17beta-estradiol modulate disease progression of a mouse model of ALS.

@article{Groeneveld2004OvariectomyA1,
  title={Ovariectomy and 17beta-estradiol modulate disease progression of a mouse model of ALS.},
  author={Geert Jan Groeneveld and Freek L van Muiswinkel and J M Sturkenboom and John H. J. Wokke and Peter Rudolf B{\"a}r and Leonard H van den Berg},
  journal={Brain research},
  year={2004},
  volume={1021 1},
  pages={128-31}
}
The incidence of amyotrophic lateral sclerosis (ALS) is higher among men than women but rises in women after the menopause. Estrogens may play a protective role. Treatment with estrogens has been shown to be neuroprotective in models of several neurodegenerative diseases. We therefore determined the effect of ovariectomy on female G93A mSOD1 transgenic mice, and the effect of subsequent treatment with 17beta-estradiol (E2). Ovariectomy led to a significant acceleration of disease progression of… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…