Ovariectomy aggravates convulsions and hippocampal gamma-aminobutyric acid inhibition induced by cyclosporin A in rats.

@article{Tominaga2001OvariectomyAC,
  title={Ovariectomy aggravates convulsions and hippocampal gamma-aminobutyric acid inhibition induced by cyclosporin A in rats.},
  author={Koji Tominaga and Atsushi Yamauchi and Hideki Shuto and Minoru Niizeki and Kazutaka Makino and Ryozo Oishi and Yasuhumi Kataoka},
  journal={European journal of pharmacology},
  year={2001},
  volume={430 2-3},
  pages={243-9}
}
The possible cyclosporin A application for rheumatoid arthritis that develops preferentially in middle-aged women raises concerns about adverse effects of cyclosporin A, including neurotoxicity in patients with climacterium. The present study was aimed at elucidating the effect of cyclosporin A on the convulsive activity and gamma-aminobutyric acid (GABA) neural activity of the hippocampus in ovariectomized rats, as a menopause/climacterium model. Ovariectomy markedly aggravated the effect of… CONTINUE READING