Ovariectomized rats as a model of postmenopausal osteoarthritis: validation and application

@article{HeghAndersen2004OvariectomizedRA,
  title={Ovariectomized rats as a model of postmenopausal osteoarthritis: validation and application},
  author={Pernille H\oegh-Andersen and L{\'a}szl{\'o} B. Tank{\'o} and Thomas Lykke Andersen and Carina Vingsbo Lundberg and John A Mo and A Heegaard and Jean-Marie Delaiss{\'e} and Stephan Christgau},
  journal={Arthritis Research & Therapy},
  year={2004},
  volume={6},
  pages={R169 - R180}
}
We aimed to assess the effect of ovariectomy on cartilage turnover and degradation, to evaluate whether ovariectomized (OVX) rats could form an experimental model of postmenopausal osteoarthritis. The effect of ovariectomy on cartilage was studied using two cohorts of female Sprague-Dawley rats, aged 5 and 7 months. In a third cohort, the effect of exogenous estrogen and a selective estrogen receptor modulator was analyzed. Knee joints were assessed by histological analysis of the articular… CONTINUE READING