Ovarian tumor initiating cell populations persist following paclitaxel and carboplatin chemotherapy treatment in vivo.

@article{KulkarniDatar2013OvarianTI,
  title={Ovarian tumor initiating cell populations persist following paclitaxel and carboplatin chemotherapy treatment in vivo.},
  author={Kashmira Kulkarni-Datar and Sandra Orsulic and Rosemary Foster and Bo Ruben Rueda},
  journal={Cancer letters},
  year={2013},
  volume={339 2},
  pages={237-46}
}
Development of recurrent platinum resistant disease following chemotherapy presents a challenge in managing ovarian cancer. Using tumors derived from genetically defined mouse ovarian cancer cells, we investigated the stem cell properties of residual cells post-chemotherapy. Utilizing CD133 and Sca-1 as markers of candidate tumor initiating cells (TIC), we determined that the relative levels of CD133+ and Sca-1+ cells were unaltered following chemotherapy. CD133+ and Sca-1+ cells exhibited… CONTINUE READING
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