Ovarian stimulation: from basic science to clinical application.

  title={Ovarian stimulation: from basic science to clinical application.},
  author={Michael A. Ludwig and Ricardo Enrique Felberbaum and Klaus Diedrich and Bruno Lunenfeld},
  journal={Reproductive biomedicine online},
  volume={22 Suppl 1},
Treatment for infertility, including ovarian stimulation, was first introduced almost 100 years ago. At this time, radiation therapy became an established treatment, and it was only some decades later that the problem of radiation-induced cancer emerged. Non-human gonadotrophins, such as pregnant mare serum gonadotrophin (PMSG), and human pituitary gonadotrophins (HPG), were commonly used for hormonal stimulation procedures. However, use of PMSG led to antibody formation, and it was therefore… CONTINUE READING


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