Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release.

@article{Pacifici1989OvarianST,
  title={Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release.},
  author={Roberto Pacifici and Leonard Rifas and Ruth McCracken and Iris Vered and Cynthia T. McMurtry and Louis V. Avioli and William A. Peck},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 7},
  pages={2398-402}
}
In previous studies, we showed that blood monocyte elaboration of interleukin 1 (IL-1), a known stimulator of bone resorption, was higher in osteoporotic patients with rapid bone turnover than in those with slow turnover and in nonosteoporotic subjects. Since an acceleration of bone loss following menopause contributes to the risk of osteoporosis in women, we have studied the effects of menopause and ovarian steroid treatment on IL-1 release by monocytes obtained from nonosteoporotic and… CONTINUE READING