Ovarian preservation by GnRH agonists during chemotherapy: a meta-analysis.

  title={Ovarian preservation by GnRH agonists during chemotherapy: a meta-analysis.},
  author={Megan E. B. Clowse and Millie A Behera and Carey K Anders and Susannah C Copland and Cynthia J. Coffman and Phyllis C. Leppert and Lori A Bastian},
  journal={Journal of women's health},
  volume={18 3},
PURPOSE Treatment with cyclophosphamide (CYC) confers up to a 40% risk of ovarian failure in women of reproductive age. The use of GnRH agonists (GnRHa) to preserve ovarian function has been investigated in several small studies. We performed a systematic review of studies examining whether a GnRHa administered during chemotherapy is protective of ovarian function and fertility. METHODS We searched the English-language literature (1966-April 2007) using MEDLINE and meeting abstracts and… CONTINUE READING
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