Ovarian malignant mixed mesodermal tumor producing the free form of the β-subunit of human chorionic gonadotropin

@article{Higashida2001OvarianMM,
  title={Ovarian malignant mixed mesodermal tumor producing the free form of the β-subunit of human chorionic gonadotropin},
  author={Taro Higashida and Tamio Koizumi and Satoshi Yamaguchi and Takaya Ichimura and Kazuo Hasegawa and Ryuichiro Nishimura},
  journal={International Journal of Clinical Oncology},
  year={2001},
  volume={6},
  pages={97-100}
}
We report a patient with ovarian malignant mixed mesodermal tumor (MMMT) that produced immunoreactive human chorionic gonadotropin β-subunit (IR-hCGβ). Qualitative analysis indicated that IR-hCGβ in the patient's serum represented the free form of the β-subunit of hCG. Immunohistochemical localization of hCGβ in MMMT was observed in the sarcomatous stroma, but not in the adenocarcinoma component. Reverse transcription-polymerase chain reaction (RT-PCR) for hCG subunits revealed that the mRNA… CONTINUE READING