Ovarian gonadotrophin surge-attenuating factor (GnSAF): where are we after 20 years of research?

@article{Fowler2003OvarianGS,
  title={Ovarian gonadotrophin surge-attenuating factor (GnSAF): where are we after 20 years of research?},
  author={P. Fowler and Tarja Sorsa-Leslie and W. Harris and H. Mason},
  journal={Reproduction},
  year={2003},
  volume={126 6},
  pages={
          689-99
        }
}
When gonadotrophin-stimulated IVF methods were being developed in the 1970s and 1980s, understanding of the physiology of FSH improved. In addition to its classic actions of stimulating aromatase activity and oestradiol secretion by ovarian granulosa cells, FSH was found to stimulate the ovarian production of an uncharacterized hormone known by its specific effect of reducing pituitary responsiveness to GnRH. This hormone has been called gonadotrophin surge-attenuating factor (GnSAF… Expand
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