Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial.

@article{Fleming2002OvarianFA,
  title={Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial.},
  author={Richard Fleming and Zoe E Hopkinson and Alan Michael Wallace and Ian Andrew Greer and Naveed 4 Sattar},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 2},
  pages={569-74}
}
Women with oligomenorrhea and polycystic ovaries show a high incidence of ovulation failure perhaps linked to insulin resistance and related metabolic features. A number of reports show that the biguanide metformin improves ovarian function. However, in these trials the quality of evidence supporting ovulation is suboptimal, and few studies have been placebo-controlled. The aim of our study was to use a double-blind, placebo-controlled approach with detailed assessment of ovarian activity (two… CONTINUE READING