Ovarian carcinoma in situ with germline BRCA1 mutation and loss of heterozygosity at BRCA1 and TP53.

@article{Werness2000OvarianCI,
  title={Ovarian carcinoma in situ with germline BRCA1 mutation and loss of heterozygosity at BRCA1 and TP53.},
  author={Bruce A Werness and Pankhuri Parvatiyar and Susan J Ramus and Alice S. Whittemore and Kim Garlinghouse-Jones and Ingrid Oakley-Girvan and Richard A. Dicioccio and Jonathan Wiest and Yoshiaki Tsukada and Bruce A. J. Ponder and M. Steven Piver},
  journal={Journal of the National Cancer Institute},
  year={2000},
  volume={92 13},
  pages={1088-91}
}
BACKGROUND The two-hit hypothesis for the genesis of cancer predicts that cancer can develop when the wild-type allele of a tumor suppressor gene is lost in an individual with a germline mutation in that gene. Neither loss of heterozygosity (LOH) for BRCA1 nor mutations of the TP53 (also known as p53) gene have been documented prior to invasion in ovarian cancers arising in women with germline BRCA1 mutations. Such documentation is difficult because lesions are rarely identified in ovarian… CONTINUE READING
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Mutation analysis of BRCA 1 , TP 53 , and KRAS 2 in ovarian and related pelvic tumors

  • H Tworek, R Peng, S Fetzer, BA Werness, MS Piver, HJ Allen
  • Cancer Genet Cytogenet
  • 1999

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