Ovarian carcinoma-associated TaqI restriction fragment length polymorphism in intron G of the progesterone receptor gene is due to an Alu sequence insertion.

@article{Rowe1995OvarianCT,
  title={Ovarian carcinoma-associated TaqI restriction fragment length polymorphism in intron G of the progesterone receptor gene is due to an Alu sequence insertion.},
  author={Simon M. Rowe and Sean J. Coughlan and Neil J. McKenna and Em Garrett and Dirk G{\"u}nter Kieback and Desmond N. Carney and Denis R. Headon},
  journal={Cancer research},
  year={1995},
  volume={55 13},
  pages={
          2743-5
        }
}
Alu sequences, short, repetitive transposable DNA elements, are factors in a number of genetic diseases. We previously identified a germline TaqI RFLP, located in intron G of the human progesterone receptor gene, that showed an association with the incidence of sporadic ovarian carcinoma. Furthermore, the polymorphism was characterized as a small (approximately 300-bp) insertion that was inherited in a Mendelian fashion. Because of its insertional character, we named this polymorphism PROGINS… CONTINUE READING

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