Ovarian carcinoma ascites spheroids adhere to extracellular matrix components and mesothelial cell monolayers.

@article{Burleson2004OvarianCA,
  title={Ovarian carcinoma ascites spheroids adhere to extracellular matrix components and mesothelial cell monolayers.},
  author={Kathryn M. Burleson and Rachael Casey and Keith M Skubitz and Stephan E Pambuccian and Theodore R. Oegema and Amy P. N. Skubitz},
  journal={Gynecologic oncology},
  year={2004},
  volume={93 1},
  pages={170-81}
}
OBJECTIVES Ovarian carcinoma cells form multicellular aggregates, or spheroids, in the peritoneal cavity of patients with advanced disease. The current paradigm that ascites spheroids are non-adhesive leaves their contribution to ovarian carcinoma dissemination undefined. Here, spheroids obtained from ovarian carcinoma patients' ascites were characterized for their ability to adhere to molecules encountered in the peritoneal cavity, with the goal of establishing their potential to contribute to… CONTINUE READING

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