Ovarian cancer mouse models: a summary of current models and their limitations

@article{Fong2009OvarianCM,
  title={Ovarian cancer mouse models: a summary of current models and their limitations},
  author={Miranda Y. Fong and Sham S. Kakar},
  journal={Journal of Ovarian Research},
  year={2009},
  volume={2},
  pages={12 - 12},
  url={https://api.semanticscholar.org/CorpusID:15419445}
}
This review focuses on the methods of various investigators and the limitations of each model in establishing a reproducible and inheritable line to study this disease.
View on Springer
ovarianresearch.biomedcentral.com
56 Citations
Background Citations
26
Methods Citations
4

56 Citations

Establishment of In Vivo Ovarian Cancer Mouse Models Using Intraperitoneal Tumor Cell Injection.

This chapter describes the methodology and approaches for generating various murine models currently employed in ovarian cancer research and covers the implantation of cells from ovarian cancer cell lines into mice by intraperitoneal injection.

Characteristics of in Vivo Model Systems for Ovarian Cancer Studies

The advantages and limitations of animal models available for basic and preclinical studies are discussed, including a syngeneic mice model and the patient derived xenograft model (PDX), both useful for pre clinical studies.

Technical challenges and limitations of current mouse models of ovarian cancer

It is found that genetic background can lead to contrasting phenotypes in one model of ovarian cancer, and data from other laboratories have also hinted that the exact genetic background of the model may influence the resulting phenotype.

The latest animal models of ovarian cancer for novel drug discovery

Advances in the development of orthotopic and patient-derived tumor xenograft (PDX) mouse models of ovarian cancer are focused on and new insight into the role of the human immune system in combating and augmenting ovarian cancer is suggested to be provided.

Single and Multiple Gene Manipulations in Mouse Models of Human Cancer

Genetic mouse models of cancers and their abilities to recapitulate human carcinoma with single versus combinatorial approaches with genes commonly involved in cancer are reviewed.

Avian as a model for human ovarian cancer: advantages reviewed

It was concluded that the spontaneous occurrence of EOC in the adult hen, the prolific ovulation, the similarity of metastatic progression with that in humans and the advantages of using the chicken embryo for modelling the development of the reproductive system, renders the hen particularly suitable for studying the early development of E OC.

The hallmarks of ovarian cancer: proliferation and cell growth

Advantages of the avian model for human ovarian cancer.

It was concluded that the spontaneous occurrence of EOC in the adult hen, the prolific ovulation, the similarity of metastatic progression with that in humans and the advantages of using the chicken embryo for modelling the development of the reproductive system, renders the hen particularly suitable for studying the early development of E OC.

Preclinical humanized mouse model with ectopic ovarian tissues

Normal human ovarian tissues were subcutaneously implanted into severe combined immunodeficient mice and then the implants were identified by immunohistochemistry and confirmed the ovarian origin of the epithelial cells.

The Use of Ovarian Cancer Cells from Patients Undergoing Surgery to Generate Primary Cultures Capable of Undergoing Functional Analysis

A robust protocol for developing primary cultures of ovarian cancer which will overcome some of the difficulties faced in the development of cell lines or animal models and is possible to derive viable ovarian cancer cell cultures in the majority of patients undergoing surgery.
...

73 References

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system.

Isolation and characterization of mouse ovarian surface epithelial cell lines.

Epithelial-stromal interaction increases cell proliferation, survival and tumorigenicity in a mouse model of human epithelial ovarian cancer.

Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer

The ovarian cancer model described in this study recapitulates the specific tumor histomorphology and metastatic potential of the human disease and shows the combination of the two mutations in the ovary leads to the induction of invasive and widely metastatic endometrioid ovarian adenocarcinomas.

Comparison of ID8 MOSE and VEGF-modified ID8 cell lines in an immunocompetent animal model for human ovarian cancer.

A clinically-relevant tool for the study of different growth patterns in ovarian cancer, with potential significance for the development of novel immunological methods, was successfully developed.

Transcriptomic analysis of an in vitro murine model of ovarian carcinoma: Functional similarity to the human disease and identification of prospective tumoral markers and targets

Findings support the utility of MOSE cells in studying ovarian cancer biology and as a source of novel diagnostic and therapeutic targets as well as identifying genes involved in ovarian tumorigenesis.

Sequential molecular and cellular events during neoplastic progression: a mouse syngeneic ovarian cancer model.

The MOSE model provides an excellent tool to identify both cellular and molecular changes in the early and late stages of ovarian cancer, to evaluate their regulation, and to determine their significance in an immunocompetent in vivo environment.

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras.

It is shown that the use of a recombinant adenovirus expressing Cre recombinase (AdenoCre) to induce K-ras G12D expression in the lungs of mice allows control of the timing and multiplicity of tumor initiation.

Early events in the pathogenesis of epithelial ovarian cancer.

A model of ovarian pathogenesis is presented that incorporates the role of tumor cell mutations and factors in the host microenvironment important to tumor initiation and progression and discusses many of the genetic and molecular disorders in each key process that is altered in cancer cells.

Development of a syngeneic mouse model for events related to ovarian cancer.

The ability of the MOSEC to form extensive tumors within the peritoneal cavity, similar to those seen in women with Stage III and IV cancer, and the ability to produce tumors in mice with intact immune systems, makes this model unique for investigations of molecular and immune interactions in ovarian cancer development.
...