Ovarian cancer cells with the CD117 phenotype are highly tumorigenic and are related to chemotherapy outcome.

@article{Luo2011OvarianCC,
  title={Ovarian cancer cells with the CD117 phenotype are highly tumorigenic and are related to chemotherapy outcome.},
  author={Lijing Luo and Jianfang Zeng and Bing Liang and Zhe Zhao and Lulu Sun and Dongyan Cao and Jiaxin Yang and Keng Shen},
  journal={Experimental and molecular pathology},
  year={2011},
  volume={91 2},
  pages={596-602}
}
Cancer stem cells (CSCs) play an important role in the recurrence and drug resistance of cancer. Isolation and characterization of CSCs from ovarian cancer samples may help to provide novel diagnostic and therapeutic targets in the management of recurrent disease and drug resistance in ovarian cancer. Here, we developed a xenograft model in which cells from 14 samples of human ovarian serous adenocarcinoma tissue or ascites were implanted in immunodeficient mice to test the tumorigenic… CONTINUE READING

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