Ovarian cancer and genetic susceptibility in relation to the BRCA1 and BRCA2 genes. Occurrence, clinical importance and intervention.

@article{Sgaard2006OvarianCA,
  title={Ovarian cancer and genetic susceptibility in relation to the BRCA1 and BRCA2 genes. Occurrence, clinical importance and intervention.},
  author={Marie S\ogaard and Susanne Kr{\"u}ger Kjaer and Simon A. Gayther},
  journal={Acta obstetricia et gynecologica Scandinavica},
  year={2006},
  volume={85 1},
  pages={93-105}
}
The Nordic countries have the highest incidences of ovarian cancer in the world (around 15 cases per 100,000 women). We have conducted a review of the recent literature with focus on the Nordic countries, on genetic susceptibility to ovarian cancer, and the clinical implications in relation to the BRCAI and BRCA2 genes. One of the strongest risk factors for ovarian cancer is a family history of ovarian and/or early-onset breast cancer. It is thought that germline mutations in BRCA1/2 might be… CONTINUE READING